Exercise capacity and biological age

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Age-dependent prognostic value of exercise capacity and derivation of fitness-associated biologic age.

OBJECTIVE Given the aging population and prevalence of sedentary behaviour in the USA, we investigated the impact of differences in exercise capacity associated with age on long-term outcomes. We derived fitness-associated 'biologic age' as a tool to encourage positive lifestyle changes. METHODS This retrospective cohort study included 57085 patients without established coronary artery diseas...

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Telomere Length and Long-Term Endurance Exercise: Does Exercise Training Affect Biological Age? A Pilot Study

BACKGROUND Telomeres are potential markers of mitotic cellular age and are associated with physical ageing process. Long-term endurance training and higher aerobic exercise capacity (VO(2max)) are associated with improved survival, and dynamic effects of exercise are evident with ageing. However, the association of telomere length with exercise training and VO(2max) has so far been inconsistent...

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Right Ventricle and Exercise Capacity

Almost 3 quarters of a century ago, an experimental dog model, involving the electrocautery ablation of the free wall of the right ventricle (RV), served as the basis for the contention that the RV serves functionally as a passive conduit. Clearly, our understanding of the RV has evolved over subsequent decades, and the prognostic significance of RV dysfunction is now recognized in a wide array...

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External prognostic validations and comparisons of age- and gender-adjusted exercise capacity predictions.

OBJECTIVES The purpose of this study was to externally validate the prognostic value of age- and gender-based nomograms and categorical definitions of impaired exercise capacity (EC). BACKGROUND Exercise capacity predicts death, but its use in routine clinical practice is hampered by its close correlation with age and gender. METHODS For a median of 5 years, we followed 22,275 patients with...

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The measurement of left ventricular ejection fraction (LVEF) plays a key role in many strategies for managing patients after acute myocardial infarction. We tested the hypothesis that exercise capacity 1 month after myocardial infarction provides additional information in patients with a low LVEF and therefore assists in risk stratification. One hundred fifteen patients, with documented myocard...

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ژورنال

عنوان ژورنال: Heart

سال: 2016

ISSN: 1355-6037,1468-201X

DOI: 10.1136/heartjnl-2015-309008